Deconstructing the pluripotency gene regulatory network
نویسندگان
چکیده
منابع مشابه
Evolution of the mammalian embryonic pluripotency gene regulatory network.
Embryonic pluripotency in the mouse is established and maintained by a gene-regulatory network under the control of a core set of transcription factors that include octamer-binding protein 4 (Oct4; official name POU domain, class 5, transcription factor 1, Pou5f1), sex-determining region Y (SRY)-box containing gene 2 (Sox2), and homeobox protein Nanog. Although this network is largely conserved...
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Stem cells of all types are characterized by a stable, heritable state permissive of multiple developmental pathways. The past five years have seen remarkable advances in understanding these heritable states and the ways that they are initiated or terminated. Transcription factors that bind directly to DNA and have sufficiency roles have been most easy to investigate and, perhaps for this reaso...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2018
ISSN: 1465-7392,1476-4679
DOI: 10.1038/s41556-018-0067-6